Lun-GenLu团队在HepatologyResearch发表学术论文“PredictionofsignificantfibrosisandcirrhosisinhepatitisBe-antigennegativepatientswithchronichepatitisBusingroutineparameters"提出一种预测模型，可以准确预测HBeAg阴性CHB患者肝纤维化及肝硬化。
Aim:Asliverbiopsyhasconsiderablelimitationsintheassessmentofliverfibrosis,non-invasivemodelshaveachievedgreatprogressinthepast.However,manytestsconsistofvariablesthatarenotreadilyavailable,andtherearefewdataaboutpatientswithHBeAgnegativeCHB.TheaimofthisstudywastodevelopamodelusingroutinedatatopredictliverfibrosisinHBeAgnegativeCHBpatients.
Methods:Werandomlydividedpatientswhounderwentliverbiopsyintotraining(n=)andvalidation(n=)sets.MultivariablelogisticregressionandROCanalyseswereusedtodevelopamodelforpredictingbothsignificantfibrosis(stages2-4)andcirrhosis(stage4)inthetrainingset.Themodelwasvalidatedinpatientsin瀹瀛曟墜鏈悗鐨勯鐤楁柟娉曟帹鑽?瀹瀛曠殑娌荤枟鎸囧鎵嬪唽
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