经常有人说一孕傻三年，意思是当女性怀孕后，记忆力会有衰退的迹象，常常会丢三落四，通常我们叫此为“孕傻”或“婴儿脑”状态。
近日，NatNeurosci杂志在线发表了一项持续5年多的研究，为一孕傻3年的原因提供了科学的依据。研究纳入第一次怀孕前后的妈妈和未产妇进行对照比较，通过脑结构MRI发现怀孕妈妈存在着社会认知相关脑区的脑灰质体积减少。有意思的是这种减少可以预测产后母性表现，表明这种调节机制服务于母爱的转化。研究者通过随访研究发现这种灰质体积减少至少持续至产后2年以上，这也解释了我们常说的一孕傻3年。
Figure2Meansofconception.SurfacemapsofGMvolumechangesbetweenthePreandPostsession(P0.05,FWE-corrected)in(a)theprimiparouswomenachievingpregnancybynaturalconception(N=9),(b)primiparouswomenachievingpregnancybyfertilitytreatment(N=16),and(c)thenulliparouscontrolwomen(N=20).
Figure3Classification.(a)Scatterplotdepictingthesupportvectormachineclassificationresults.Functionvalues(mean±s.d.):FPRG:1.27±1.03,FCTR:?0.79±0.33.Balancedaccuracy:%,althoughsomeparticipantsareclosetothedecisionfunctionborder;dashedlineisthefunctionvaluecut-offbetweenclasses(0),leave-one-outcross-validation,Npermutations=10,,P≤0.1.Functionvaluesareplottedperfold(i.e.,inthiscase,persubject).(b)Weightmapfortheclassifier,depictingtherelativecontributionofthevoxeltothedecisionfunction.(c)Weightmapsfortheregionsofgreatestpredictivepowerresultingfromthemultiple-kernellearningmodelusingtheAutomatedAnatomicalLabeling(AAL)atlas(balancedaccuracy:93.5%,leave-one-outcross-validation,Npermutations=10,,P≤0.1).Theseare(depictedfromlefttoright)therightmiddletemporalgyrus(weight22.46%,experimentalranking1.2),therightinferiorfrontalgyrus(weight19.46%,experimentalranking1.84)
andtherightposteriorcingulatecortex(weight10.41%,experimentalranking3.98).FCTR,nulliparouscontrolwomenwhowerenotpregnantbetweensessions;FPRG,nulliparouswomenwhobecamepregnantandgavebirthbetweensessions.
Figure4Similaritybetweentheory-of-mindnetworkandGMvolumechangesofpregnancy.(a)Thetheory-of-mindnetworkasextractedfromthemeta-analysisbySchurzetal.22.Statisticalmapofpermutation-basedz-valuesofthepooledmeta-analysiswasprovidedbySchurzetal.22anddisplayedusingCaretsoftware.(b)ReductionsinGMvolume(P0.05,FWE-corrected)inthegroupofwomenwhowerepregnantbetweensessionsinthecurrentstudy.
Figure5Surface-basedmeasures.Surfacemapsdepictingchangesin(a)surfaceareaand(b)corticalthicknessacrosspregnancy(falsediscoveryrate(FDR)-correctedP0.05).Blueandcyanreflectincreaseswhileredandyellowreflectdecreases.
Figure6Postpartuminfant-relatedneuralactivityandattachmentscores.(a)fMRIresultsforthe‘ownotherbaby’contrast(N=20)alongsideGMvolumechangesrepeatedfromFigure1.Forillustrativepurposes,thefMRIresultsaredepictedatthemorelenientthresholdofP0.1uncorrected(therightinferiorfrontalclusterandatrendfortheposteriorcingulatecortexareobservedattheP0.05FWE-correctedthreshold;seeSupplementaryTable11).Therewerenostatisticallysignificantresultsforthe‘otherown’babypicturescontrastateitherthreshold.(b)MultivariatepredictionofMaternalPostpartumAttachmentScale(MPAS)scoresbasedontheGMvolumechangesofpregnancy.Multivariatekernelridgeregressionresults(N=24,leave-one-outcross-validation)withtheMPASscores(Npermutations=10,.Qualityofattachment:mean±s.d.=37.11±3.99.P=0.,pnMSE=0..Absenceofhostility:mean±s.d.=16.93±4.10.P=0.,pnMSE=0..Pleasureininteraction:mean±s.d.=20.88±3.10.P=0.,pnMSE=0.).PredictedversusactualMPASscoresareplottedforthetwoMPASscoresthatwerefoundtobeassociatedwiththeGMvolumechanges;nMSE,normalizedmeansquarederror.
Figure7Long-termfollow-up.(a)Mean(±s.e.m.)signalchangeateachPostsessionrelativetothePrebaseline,extractedfromthesmoothednormalizedjacobiandifferenceimages.TheremainingclustersareplottedinSupplementaryFigure1.(b)SurfacemapsdepictingGMvolumereductionsinthePost+2yearssession广州治白癜风最好的医院白癜风如何治
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